[HTML][HTML] Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen
Group B Streptococcus (GBS) is the leading cause of neonatal septicemia and meningitis.
Pili appendages were shown to play a critical role in bacterial adhesion and colonization of
human tissues. Recently it was claimed that binding of the pilus-associated adhesin PilA to
collagen is a critical, initial step in promoting interactions with the α2β1 integrin expressed
on brain endothelial cells. Here we show that strain NCTC10/84 used in this study is not
representative for GBS isolates and question the importance of collagen as a critical …
Pili appendages were shown to play a critical role in bacterial adhesion and colonization of
human tissues. Recently it was claimed that binding of the pilus-associated adhesin PilA to
collagen is a critical, initial step in promoting interactions with the α2β1 integrin expressed
on brain endothelial cells. Here we show that strain NCTC10/84 used in this study is not
representative for GBS isolates and question the importance of collagen as a critical …
