[HTML][HTML] Memory T cell–mediated rejection is mitigated by FcγRIIB expression on CD8+ T cells
AB Morris, DF Pinelli, D Liu, M Wagener… - American Journal of …, 2020 - Elsevier
Donor-reactive memory T cells generated via heterologous immunity represent a potent
barrier to long-term graft survival following transplantation because of their increased
precursor frequency, rapid effector function, altered trafficking patterns, and reduced reliance
on costimulation signals for activation. Thus, the identification of pathways that control
memory T cell survival and secondary recall potential may provide new opportunities for
therapeutic intervention. Here, we discovered that donor-specific effector/memory CD8+ T …
barrier to long-term graft survival following transplantation because of their increased
precursor frequency, rapid effector function, altered trafficking patterns, and reduced reliance
on costimulation signals for activation. Thus, the identification of pathways that control
memory T cell survival and secondary recall potential may provide new opportunities for
therapeutic intervention. Here, we discovered that donor-specific effector/memory CD8+ T …