Circulating alloreactive T cells correlate with graft function in longstanding renal transplant recipients
O Bestard, P Nickel, JM Cruzado… - Journal of the …, 2008 - journals.lww.com
Monitoring for alloreactive memory T cells after organ transplantation may allow
individualization of immunosuppression. Two pathways of T cell allorecognition have been
implicated in chronic graft dysfunction: Direct (recipient T cells respond to donor peptides
presented by donor antigen-presenting cells) and indirect (donor peptides are processed
and presented by recipient antigen-presenting cells). Previous studies have assessed these
alloresponses only during the first 2 yr after kidney transplantation, so this study correlated …
individualization of immunosuppression. Two pathways of T cell allorecognition have been
implicated in chronic graft dysfunction: Direct (recipient T cells respond to donor peptides
presented by donor antigen-presenting cells) and indirect (donor peptides are processed
and presented by recipient antigen-presenting cells). Previous studies have assessed these
alloresponses only during the first 2 yr after kidney transplantation, so this study correlated …