[HTML][HTML] Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection
K Setoguchi, Y Hattori, S Iida, WM Baldwin III… - American Journal of …, 2013 - Elsevier
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts within 12–24
h posttransplant in mice and are activated to proliferate and produce IFN-γ. To more
accurately assess the graft injury directly imposed by these endogenous memory CD8 T
cells, we took advantage of the ability of anti-LFA-1 mAb given to allograft recipients on days
3 and 4 posttransplant to inhibit the generation of primary effector T cells. When compared to
grafts from IgG-treated recipients on day 7 posttransplant, allografts from anti-LFA-1 mAb …
h posttransplant in mice and are activated to proliferate and produce IFN-γ. To more
accurately assess the graft injury directly imposed by these endogenous memory CD8 T
cells, we took advantage of the ability of anti-LFA-1 mAb given to allograft recipients on days
3 and 4 posttransplant to inhibit the generation of primary effector T cells. When compared to
grafts from IgG-treated recipients on day 7 posttransplant, allografts from anti-LFA-1 mAb …