[HTML][HTML] Modulation of ten-eleven translocation 1 (TET1), isocitrate dehydrogenase (IDH) expression, α-ketoglutarate (α-KG), and DNA hydroxymethylation levels by …
5-Hydroxymethylcytosine (5-hmC) generated by ten-eleven translocation 1–3 (TET1–3)
enzymes is an epigenetic mark present in many tissues with different degrees of abundance.
IL-1β and TNF-α are the two major cytokines present in arthritic joints that modulate the
expression of many genes associated with cartilage degradation in osteoarthritis. In the
present study, we investigated the global 5-hmC content, the effects of IL-1β and TNF-α on 5-
hmC content, and the expression and activity of TETs and isocitrate dehydrogenases in …
enzymes is an epigenetic mark present in many tissues with different degrees of abundance.
IL-1β and TNF-α are the two major cytokines present in arthritic joints that modulate the
expression of many genes associated with cartilage degradation in osteoarthritis. In the
present study, we investigated the global 5-hmC content, the effects of IL-1β and TNF-α on 5-
hmC content, and the expression and activity of TETs and isocitrate dehydrogenases in …