[HTML][HTML] Endoglin promotes transforming growth factor β-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC
Transforming growth factor β (TGF-β) signals through two distinct pathways to regulate
endothelial cell proliferation, migration, and angiogenesis, the ALK-1/Smad 1/5/8 and ALK-
5/Smad2/3 pathways. Endoglin is a co-receptor predominantly expressed in endothelial
cells that participates in TGFβ-mediated signaling with ALK-1 and ALK-5 and regulates
critical aspects of cellular and biological responses. The embryonic lethal phenotype of
knock-out mice because of defects in angiogenesis and disease-causing mutations resulting …
endothelial cell proliferation, migration, and angiogenesis, the ALK-1/Smad 1/5/8 and ALK-
5/Smad2/3 pathways. Endoglin is a co-receptor predominantly expressed in endothelial
cells that participates in TGFβ-mediated signaling with ALK-1 and ALK-5 and regulates
critical aspects of cellular and biological responses. The embryonic lethal phenotype of
knock-out mice because of defects in angiogenesis and disease-causing mutations resulting …