Phospholipid composition and ultrastructure of A549 cells and other cultured pulmonary epithelial cells of presumed type II cell origin
RJ Mason, MC Williams - Biochimica et Biophysica Acta (BBA)-Lipids and …, 1980 - Elsevier
In order to assess the usefulness of A549, L-2, and AK-D cell lines as model systems for
alveolar type II cells, we compared their phospholipid composition to that of fibroblasts
grown under similar conditions. The percentage of disaturated phosphatidylcholine and
phosphatidylglycerol, key phospholipids of purified surface-active material, was the same in
epithelial cells and fibro-blasts. When A549 cells were maintained in serum-free media for
two days, ultrastructural examination showed an increase in cytoplasmic lamellar inclusions …
alveolar type II cells, we compared their phospholipid composition to that of fibroblasts
grown under similar conditions. The percentage of disaturated phosphatidylcholine and
phosphatidylglycerol, key phospholipids of purified surface-active material, was the same in
epithelial cells and fibro-blasts. When A549 cells were maintained in serum-free media for
two days, ultrastructural examination showed an increase in cytoplasmic lamellar inclusions …