Effects of mTOR inhibition on normal retinal vascular development in the mouse
R Yagasaki, T Nakahara, A Mori, K Sakamoto… - Experimental Eye …, 2014 - Elsevier
We aimed to determine the role of age-related changes in the mammalian target of
rapamycin (mTOR) activity in endothelial cell growth during retinal vascular development in
mice. Mice were administered the mTOR inhibitor rapamycin as follows:(i) for 6 days from
postnatal day 0 (P0) to P5,(ii) for 2 days on P6 and P7, and (iii) for 2 days on P12 and P13.
For comparison, we examined the effects of KRN633, an inhibitor of vascular endothelial
growth factor (VEGF) receptor tyrosine kinase, on retinal vascular development. The retinal …
rapamycin (mTOR) activity in endothelial cell growth during retinal vascular development in
mice. Mice were administered the mTOR inhibitor rapamycin as follows:(i) for 6 days from
postnatal day 0 (P0) to P5,(ii) for 2 days on P6 and P7, and (iii) for 2 days on P12 and P13.
For comparison, we examined the effects of KRN633, an inhibitor of vascular endothelial
growth factor (VEGF) receptor tyrosine kinase, on retinal vascular development. The retinal …