[HTML][HTML] The landscape of histone modifications in a high-fat diet-induced obese (DIO) mouse model
L Nie, L Shuai, M Zhu, P Liu, ZF Xie, S Jiang… - Molecular & Cellular …, 2017 - ASBMB
Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence
suggests that a histone-modification-mediated epigenetic mechanism underlies T2D.
Nevertheless, the dynamics of histone marks in T2D have not yet been carefully analyzed.
Using a mass spectrometry-based label-free and chemical stable isotope labeling
quantitative proteomic approach, we systematically profiled liver histone post-translational
modifications (PTMs) in a prediabetic high-fat diet-induced obese (DIO) mouse model. We …
suggests that a histone-modification-mediated epigenetic mechanism underlies T2D.
Nevertheless, the dynamics of histone marks in T2D have not yet been carefully analyzed.
Using a mass spectrometry-based label-free and chemical stable isotope labeling
quantitative proteomic approach, we systematically profiled liver histone post-translational
modifications (PTMs) in a prediabetic high-fat diet-induced obese (DIO) mouse model. We …