Allergen immunotherapy is effective for the treatment of allergic rhinitis, allergic asthma, and
Hymenoptera venom allergy. In view of potential side effects, cost, and the necessary patient
commitment, an important question is whether allergen immunotherapy provides persistent
clinical benefits after treatment discontinuation. Here, we appraise the existing evidence for
long-term effects of both subcutaneous and sublingual immunotherapy in terms of clinical
efficacy, immune mechanisms, prevention of asthma development, and prevention of new …