[HTML][HTML] The impact of c4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy
A Haririan, B Kiangkitiwan, D Kukuruga… - American Journal of …, 2009 - Elsevier
We examined the pattern of PTC C4d by immunohistochemistry and DSA in 297 kidney
recipients with indication biopsies, and evaluated their predictive value for graft survival.
Median biopsy time was 5.1 months posttransplant. Patients were followed for 17.9±9.4
months postbiopsy. An 18.5% had focal and 15.2% had diffuse C4d, with comparable graft
survival (adjusted graft failure HR: 2.3, p= 0.001; HR: 1.9, p< 0.02, respectively). 31.3% were
DSA+, 19.5% class I and 22.9% class II DSA. Only those with class II DSA had worse …
recipients with indication biopsies, and evaluated their predictive value for graft survival.
Median biopsy time was 5.1 months posttransplant. Patients were followed for 17.9±9.4
months postbiopsy. An 18.5% had focal and 15.2% had diffuse C4d, with comparable graft
survival (adjusted graft failure HR: 2.3, p= 0.001; HR: 1.9, p< 0.02, respectively). 31.3% were
DSA+, 19.5% class I and 22.9% class II DSA. Only those with class II DSA had worse …