Evaluation of intravitreal 5-fluorouracil, vincristine, VP 16, doxorubicin, and thiotepa in primate eyes.
A Barrada, GA Peyman, J Case, G Fishman… - Ophthalmic …, 1984 - europepmc.org
A Barrada, GA Peyman, J Case, G Fishman, A Thomas, R Fiscella
Ophthalmic surgery, 1984•europepmc.orgA single intravitreal dose of 750 micrograms 5 fluorouracil (5 FU) or 5 micrograms
doxorubicin were nontoxic to primate eyes. A concentration of 250 micrograms/ml of 5 FU in
the vitrectomy infusion fluid in combination with 8 micrograms/ml of thiotepa, with 40
micrograms/ml of VP16 (etoposide), or with either. 04 or. 02 microgram/ml of vincristine was
also well tolerated by the primate eye. 5 micrograms/ml of doxorubicin in the vitrectomy
infusion fluid did not cause apparent toxicity to the retina. Toxic effects were noted in eyes …
doxorubicin were nontoxic to primate eyes. A concentration of 250 micrograms/ml of 5 FU in
the vitrectomy infusion fluid in combination with 8 micrograms/ml of thiotepa, with 40
micrograms/ml of VP16 (etoposide), or with either. 04 or. 02 microgram/ml of vincristine was
also well tolerated by the primate eye. 5 micrograms/ml of doxorubicin in the vitrectomy
infusion fluid did not cause apparent toxicity to the retina. Toxic effects were noted in eyes …
A single intravitreal dose of 750 micrograms 5 fluorouracil (5 FU) or 5 micrograms doxorubicin were nontoxic to primate eyes. A concentration of 250 micrograms/ml of 5 FU in the vitrectomy infusion fluid in combination with 8 micrograms/ml of thiotepa, with 40 micrograms/ml of VP16 (etoposide), or with either. 04 or. 02 microgram/ml of vincristine was also well tolerated by the primate eye. 5 micrograms/ml of doxorubicin in the vitrectomy infusion fluid did not cause apparent toxicity to the retina. Toxic effects were noted in eyes receiving 250 micrograms of 5 FU in combination with either. 15 or. 1 microgram/ml of vincristine.
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