Effect of intravitreal aflibercept vs laser photocoagulation on treatment success of retinopathy of prematurity: the FIREFLEYE randomized clinical trial
A Stahl, EA Sukgen, WC Wu, D Lepore, H Nakanishi… - Jama, 2022 - jamanetwork.com
Importance Laser photocoagulation, which is the standard treatment for retinopathy of
prematurity (ROP), can have adverse events. Studies of anti–vascular endothelial growth
factor injections have suggested efficacy in the treatment of ROP, but few studies have
directly compared them with laser treatments. Objective To compare intravitreal aflibercept
vs laser photocoagulation in infants with ROP requiring treatment. Design, Setting, and
Participants This noninferiority, phase 3, 24-week, randomized clinical trial was conducted in …
prematurity (ROP), can have adverse events. Studies of anti–vascular endothelial growth
factor injections have suggested efficacy in the treatment of ROP, but few studies have
directly compared them with laser treatments. Objective To compare intravitreal aflibercept
vs laser photocoagulation in infants with ROP requiring treatment. Design, Setting, and
Participants This noninferiority, phase 3, 24-week, randomized clinical trial was conducted in …
