[HTML][HTML] Viruses, stemness, embryogenesis, and cancer: a miracle leap toward molecular definition of novel oncotargets for therapy-resistant malignant tumors?
GV Glinsky - Oncoscience, 2015 - ncbi.nlm.nih.gov
Oncoscience, 2015•ncbi.nlm.nih.gov
Recent breakthrough studies documented consistent activation of specific endogenous
retroviruses in human embryonic stem cells and preimplantation human embryos and
demonstrated the essential role of the sustained retroviral activities for maintenance of
pluripotency and embryonic stem cell identity. Present analysis has led to the hypothesis
that activation of the human stem cell-associated retroviruses (SCARs), namely
LTR7/HERVH and LTR5_Hs/HERVK, is likely associated with the emergence of clinically …
retroviruses in human embryonic stem cells and preimplantation human embryos and
demonstrated the essential role of the sustained retroviral activities for maintenance of
pluripotency and embryonic stem cell identity. Present analysis has led to the hypothesis
that activation of the human stem cell-associated retroviruses (SCARs), namely
LTR7/HERVH and LTR5_Hs/HERVK, is likely associated with the emergence of clinically …
Abstract
Recent breakthrough studies documented consistent activation of specific endogenous retroviruses in human embryonic stem cells and preimplantation human embryos and demonstrated the essential role of the sustained retroviral activities for maintenance of pluripotency and embryonic stem cell identity. Present analysis has led to the hypothesis that activation of the human stem cell-associated retroviruses (SCARs), namely LTR7/HERVH and LTR5_Hs/HERVK, is likely associated with the emergence of clinically lethal therapy resistant death-from-cancer phenotypes in a sub-set of cancer patients diagnosed with different types of malignant tumors.
ncbi.nlm.nih.gov