[HTML][HTML] L-serine deficiency elicits intracellular accumulation of cytotoxic deoxysphingolipids and lipid body formation
K Esaki, T Sayano, C Sonoda, T Akagi, T Suzuki… - Journal of biological …, 2015 - ASBMB
l-Serine is required to synthesize membrane lipids such as phosphatidylserine and
sphingolipids. Nevertheless, it remains largely unknown how a diminished capacity to
synthesize l-serine affects lipid homeostasis in cells and tissues. Here, we show that
deprivation of external l-serine leads to the generation of 1-deoxysphingolipids (doxSLs),
including 1-deoxysphinganine, in mouse embryonic fibroblasts (KO-MEFs) lacking d-3-
phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step in the de novo …
sphingolipids. Nevertheless, it remains largely unknown how a diminished capacity to
synthesize l-serine affects lipid homeostasis in cells and tissues. Here, we show that
deprivation of external l-serine leads to the generation of 1-deoxysphingolipids (doxSLs),
including 1-deoxysphinganine, in mouse embryonic fibroblasts (KO-MEFs) lacking d-3-
phosphoglycerate dehydrogenase (Phgdh), which catalyzes the first step in the de novo …