Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease
Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney
disease are available. This study used gas chromatography-mass spectrometry to quantify
94 urine metabolites in screening and validation cohorts of patients with diabetes mellitus
(DM) and CKD (DM+ CKD), in patients with DM without CKD (DM–CKD), and in healthy
controls. Compared with levels in healthy controls, 13 metabolites were significantly reduced
in the DM+ CKD cohorts (P≤ 0.001), and 12 of the 13 remained significant when compared …
disease are available. This study used gas chromatography-mass spectrometry to quantify
94 urine metabolites in screening and validation cohorts of patients with diabetes mellitus
(DM) and CKD (DM+ CKD), in patients with DM without CKD (DM–CKD), and in healthy
controls. Compared with levels in healthy controls, 13 metabolites were significantly reduced
in the DM+ CKD cohorts (P≤ 0.001), and 12 of the 13 remained significant when compared …