Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases
YS Chun, JN Vauthey, P Boonsirikamchai, DM Maru… - Jama, 2009 - jamanetwork.com
Context The standard criteria used to evaluate tumor response, the Response Evaluation
Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic
chemotherapy and may be limited in assessing response to biologic agents, which have a
cytostatic mechanism of action. Objective To validate novel tumor response criteria based on
morphologic changes observed on computed tomography (CT) in patients with colorectal
liver metastases treated with bevacizumab-containing chemotherapy regimens. Design …
Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic
chemotherapy and may be limited in assessing response to biologic agents, which have a
cytostatic mechanism of action. Objective To validate novel tumor response criteria based on
morphologic changes observed on computed tomography (CT) in patients with colorectal
liver metastases treated with bevacizumab-containing chemotherapy regimens. Design …
