Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells
YW Tien, YM Wu, WC Lin, HS Lee, PH Lee - Journal of hepatology, 2009 - Elsevier
BACKGROUND/AIMS: Pancreatic ductal carcinoma cells induce fibrosis by stimulating
pancreatic stellate cells to proliferate and synthesize matrix. Desmoplastic reaction has also
been observed in liver metastases of pancreatic carcinoma. Hepatic stellate cells are similar
to pancreatic stellate cells and may contribute to the desmoplasia associated with liver
metastases of pancreatic cancer. The aim of this study was to determine the role of hepatic
stellate cells in metastasis. METHODS: Markers of the desmoplastic reaction in tumors …
pancreatic stellate cells to proliferate and synthesize matrix. Desmoplastic reaction has also
been observed in liver metastases of pancreatic carcinoma. Hepatic stellate cells are similar
to pancreatic stellate cells and may contribute to the desmoplasia associated with liver
metastases of pancreatic cancer. The aim of this study was to determine the role of hepatic
stellate cells in metastasis. METHODS: Markers of the desmoplastic reaction in tumors …
