[HTML][HTML] Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation
RL Pan, P Wang, LX Xiang, JZ Shao - Journal of Biological Chemistry, 2011 - ASBMB
Chronic liver injury always progresses to fibrosis and eventually to cirrhosis, a massive
health care burden worldwide. Delta-like 1 (Dlk1) is well known as an inhibitor of adipocyte
differentiation. However, whether it is involved in liver fibrosis remains unclear. Here, we
provide the first evidence that Dlk1 is a critical contributor to liver fibrosis through promoting
activation of hepatic stellate cells (HSCs) during chronic liver injury. We found that upon liver
injury, Dlk1 was dramatically induced and initially expressed in hepatocytes and then into …
health care burden worldwide. Delta-like 1 (Dlk1) is well known as an inhibitor of adipocyte
differentiation. However, whether it is involved in liver fibrosis remains unclear. Here, we
provide the first evidence that Dlk1 is a critical contributor to liver fibrosis through promoting
activation of hepatic stellate cells (HSCs) during chronic liver injury. We found that upon liver
injury, Dlk1 was dramatically induced and initially expressed in hepatocytes and then into …