Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in
hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is
relevant to hepatic inflammation, fibrosis, and cancer because of its anti-oxidative properties;
however, the regulation of CYGB gene expression remains unknown. Here, we sought to
identify factors that induce CYGB expression in HSCs and to clarify the molecular
mechanism involved. We used the human HSC cell line HHSteC and primary human HSCs …