[HTML][HTML] Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein
E Tassi, A Al-Attar, A Aigner, MR Swift… - Journal of Biological …, 2001 - ASBMB
Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind
fibroblast growth factors (FGFs) 1 and 2. These FGFs are typically stored on heparan sulfate
proteoglycans in the extracellular matrix in an inactive form, and it has been proposed that
FGF-BP1 functions as a chaperone molecule that can mobilize locally stored FGF and
present the growth factor to its tyrosine kinase receptor. FGF-BP1 is up-regulated in
squamous cell, colon, and breast cancers and can act as an angiogenic switch during …
fibroblast growth factors (FGFs) 1 and 2. These FGFs are typically stored on heparan sulfate
proteoglycans in the extracellular matrix in an inactive form, and it has been proposed that
FGF-BP1 functions as a chaperone molecule that can mobilize locally stored FGF and
present the growth factor to its tyrosine kinase receptor. FGF-BP1 is up-regulated in
squamous cell, colon, and breast cancers and can act as an angiogenic switch during …