Modulation of extracellular matrix turnover in the trabecular meshwork
R Fuchshofer, ER Tamm - Experimental eye research, 2009 - Elsevier
Intraocular pressure (IOP) is the most critical risk factor for primary open angle glaucoma
(POAG). In most cases of POAG, IOP is increased because of an abnormally high aqueous
humor outflow resistance in the juxtacanalicular region of the trabecular meshwork. A
distinct structural change in the trabecular meshwork of patients with POAG is the increase
in fibrillar extracellular matrix in the juxtacanalicular region of the trabecular meshwork. Our
knowledge on the molecular factors that govern turnover of the extracellular matrix in the …
(POAG). In most cases of POAG, IOP is increased because of an abnormally high aqueous
humor outflow resistance in the juxtacanalicular region of the trabecular meshwork. A
distinct structural change in the trabecular meshwork of patients with POAG is the increase
in fibrillar extracellular matrix in the juxtacanalicular region of the trabecular meshwork. Our
knowledge on the molecular factors that govern turnover of the extracellular matrix in the …
