Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis
M Gersemann, S Becker, I Kübler, M Koslowski… - Differentiation, 2009 - Elsevier
Goblet cells are mucin-secreting intestinal cells forming the mucus layer that protects the
mucosal surface. Ulcerative colitis (UC) has been associated with a defective colonic mucus
layer and a reduced number of goblet cells. In experimental animals, colonic goblet cell
differentiation is regulated by interacting transcription factors Hath1, KLF4 and the Notch, as
well as Wnt pathways, whereas data in humans are limited. We investigated goblet cell
differentiation factors and mucins in controls and in inflammatory bowel diseases (IBDs). We …
mucosal surface. Ulcerative colitis (UC) has been associated with a defective colonic mucus
layer and a reduced number of goblet cells. In experimental animals, colonic goblet cell
differentiation is regulated by interacting transcription factors Hath1, KLF4 and the Notch, as
well as Wnt pathways, whereas data in humans are limited. We investigated goblet cell
differentiation factors and mucins in controls and in inflammatory bowel diseases (IBDs). We …
