The gastrointestinal epithelium is covered by a protective mucus gel composed
predominantly of mucin glyco-proteins that are synthesized and secreted by goblet cells.
Changes in goblet cell functions and in the chemical composition of intestinal mucus are
detected in response to a broad range of luminal insults, including alterations of the normal
microbiota. However, the regulatory networks that mediate goblet cell responses to intestinal
insults are poorly defined. The present review summarizes the results of developmental …