The pathogenesis of non-alcoholic fatty liver disease, particularly the mechanisms whereby
a minority of patients develop a more severe phenotype characterised by hepatocellular
damage, inflammation, and fibrosis is still incompletely understood. Herein, we discuss two
pivotal aspects of the pathogenesis of NASH. We first analyse the initial mechanisms
responsible for hepatocellular damage and inflammation, which derive from the toxic effects
of excess lipids. Accumulating data indicate that the total amount of triglycerides stored in …