Down-regulation of SREBP-1c is associated with the development of burned-out NASH
T Nagaya, N Tanaka, T Suzuki, K Sano, A Horiuchi… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: It is well-known that hepatic triglycerides (TG) diminish with the
progression of non-alcoholic steatohepatitis (NASH), which has been designated as burned-
out NASH, but its mechanism remains unclear. We aimed to explore the changes in hepatic
fatty acid (FA) and TG metabolism with disease progression. METHODS: Hepatic expression
of key genes in healthy individuals (n= 6) and patients with simple steatosis (SS, n= 10), mild
NASH (fibrosis stage 1–2, n= 20), and advanced NASH (fibrosis stage 3–4, n= 20) were …
progression of non-alcoholic steatohepatitis (NASH), which has been designated as burned-
out NASH, but its mechanism remains unclear. We aimed to explore the changes in hepatic
fatty acid (FA) and TG metabolism with disease progression. METHODS: Hepatic expression
of key genes in healthy individuals (n= 6) and patients with simple steatosis (SS, n= 10), mild
NASH (fibrosis stage 1–2, n= 20), and advanced NASH (fibrosis stage 3–4, n= 20) were …