Nuclear receptor transcription factors are ligand-activated proteins that control various
biological events from cell growth and development to lipid metabolism, and energy and
glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases.
Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential roles in
regulation of cholesterol, triglyceride, fatty acid, and glucose homeostasis. LXR-deficient
mice have shown the association of LXR-signaling pathway dysfunction with several human …