Protective effect of C5a receptor inhibition after murine reperfused stroke
GH Kim, J Mocco, DK Hahn, CP Kellner… - …, 2008 - journals.lww.com
OBJECTIVE The complement cascade has been implicated in cerebral ischemia/reperfusion
injury. To develop clinically useful therapies that successfully manipulate the complement
cascade, the individual roles of its components must be clearly defined. Previous studies
have shown that C5 inhibition improves outcome after experimental stroke. In this study, we
investigated the role of C5a in stroke injury by inhibiting its activity at the receptor level.
METHODS C5a receptor antagonist or vehicle was administered to mice before temporary …
injury. To develop clinically useful therapies that successfully manipulate the complement
cascade, the individual roles of its components must be clearly defined. Previous studies
have shown that C5 inhibition improves outcome after experimental stroke. In this study, we
investigated the role of C5a in stroke injury by inhibiting its activity at the receptor level.
METHODS C5a receptor antagonist or vehicle was administered to mice before temporary …
