[HTML][HTML] Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis
AM Timmer, JC Timmer, MA Pence, LC Hsu… - Journal of Biological …, 2009 - ASBMB
Group A Streptococcus (GAS) is a leading human bacterial pathogen capable of producing
invasive infections even in previously healthy individuals. As frontline components of host
innate defense, macrophages play a key role in control and clearance of GAS infections. We
find GAS induces rapid, dose-dependent apoptosis of primary and cultured macrophages
and neutrophils. The cell death pathway involves apoptotic caspases, is partly dependent on
caspase-1, and requires GAS internalization by the phagocyte. Analysis of GAS virulence …
invasive infections even in previously healthy individuals. As frontline components of host
innate defense, macrophages play a key role in control and clearance of GAS infections. We
find GAS induces rapid, dose-dependent apoptosis of primary and cultured macrophages
and neutrophils. The cell death pathway involves apoptotic caspases, is partly dependent on
caspase-1, and requires GAS internalization by the phagocyte. Analysis of GAS virulence …