BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood–brain-barrier
R Araya, M Kudo, M Kawano, K Ishii… - Molecular and Cellular …, 2008 - Elsevier
Bone morphogenetic protein (BMP) signaling is involved in differentiation of neural
precursor cells into astrocytes, but its contribution to angiogenesis is not well characterized.
This study examines the role of BMP signaling through BMP type IA receptor (BMPRIA) in
early neural development using a conditional knockout mouse model, in which Bmpr1a is
selectively disrupted in telencephalic neural stem cells. The conditional mutant mice show a
significant increase in the number of cerebral blood vessels and the level of vascular …
precursor cells into astrocytes, but its contribution to angiogenesis is not well characterized.
This study examines the role of BMP signaling through BMP type IA receptor (BMPRIA) in
early neural development using a conditional knockout mouse model, in which Bmpr1a is
selectively disrupted in telencephalic neural stem cells. The conditional mutant mice show a
significant increase in the number of cerebral blood vessels and the level of vascular …