[HTML][HTML] Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease
JL Wittnam, E Portelius, H Zetterberg… - Journal of Biological …, 2012 - ASBMB
Pyroglutamate-modified Aβ peptides at amino acid position three (Aβ pE3–42) are gaining
considerable attention as potential key players in the pathogenesis of Alzheimer disease
(AD). Aβ pE3–42 is abundant in AD brain and has a high aggregation propensity, stability
and cellular toxicity. The aim of the present work was to study the direct effect of elevated Aβ
pE3–42 levels on ongoing AD pathology using transgenic mouse models. To this end, we
generated a novel mouse model (TBA42) that produces Aβ pE3–42. TBA42 mice showed …
considerable attention as potential key players in the pathogenesis of Alzheimer disease
(AD). Aβ pE3–42 is abundant in AD brain and has a high aggregation propensity, stability
and cellular toxicity. The aim of the present work was to study the direct effect of elevated Aβ
pE3–42 levels on ongoing AD pathology using transgenic mouse models. To this end, we
generated a novel mouse model (TBA42) that produces Aβ pE3–42. TBA42 mice showed …
