[HTML][HTML] TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane …
E Buratti, A Brindisi, M Giombi, S Tisminetzky… - Journal of Biological …, 2005 - ASBMB
TDP-43 is a highly conserved nuclear factor of yet unknown function that binds to ug-
repeated sequences and is responsible for cystic fibrosis transmembrane conductance
regulator exon 9 splicing inhibition. We have analyzed TDP-43 interactions with other
splicing factors and identified the critical regions for the protein/protein recognition events
that determine this biological function. We show here that the C-terminal region of TDP-43 is
capable of binding directly to several proteins of the heterogeneous nuclear …
repeated sequences and is responsible for cystic fibrosis transmembrane conductance
regulator exon 9 splicing inhibition. We have analyzed TDP-43 interactions with other
splicing factors and identified the critical regions for the protein/protein recognition events
that determine this biological function. We show here that the C-terminal region of TDP-43 is
capable of binding directly to several proteins of the heterogeneous nuclear …