Bcl-2 mediates chemoresistance in matched pairs of primary Eμ-myc lymphomas in vivo
CA Schmitt, SW Lowe - Blood Cells, Molecules, and Diseases, 2001 - Elsevier
The oncoprotein Bcl-2 is a potent survival factor antagonizing p53-dependent and-
independent apoptotic cell death. Although many anticancer agents are known to engage
apoptotic pathways, the clinical impact of Bcl-2 on treatment outcome remains controversial.
Since it might be difficult to assess the contribution of a single gene to treatment response in
patient material due to technical considerations, we sought to address Bcl-2's role in a
mouse model of primary lymphomas treated at their natural site. Driven by the Eμ-enhancer …
independent apoptotic cell death. Although many anticancer agents are known to engage
apoptotic pathways, the clinical impact of Bcl-2 on treatment outcome remains controversial.
Since it might be difficult to assess the contribution of a single gene to treatment response in
patient material due to technical considerations, we sought to address Bcl-2's role in a
mouse model of primary lymphomas treated at their natural site. Driven by the Eμ-enhancer …