The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners
M Rosner, M Hanneder, N Siegel, A Valli… - … Research/Reviews in …, 2008 - Elsevier
Mutations in the tumor suppressor genes TSC1 and TSC2, encoding hamartin and tuberin,
respectively, cause the tumor syndrome tuberous sclerosis with similar phenotypes. Until
now, over 50 proteins have been demonstrated to interact with hamartin and/or tuberin.
Besides tuberin, the proteins DOCK7, ezrin/radixin/moesin, FIP200, IKKβ, Melted, Merlin,
NADE (p75NTR), NF-L, Plk1 and TBC7 have been found to interact with hamartin. Whereas
Plk1 and TBC7 have been demonstrated not to bind to tuberin, for all the other hamartin …
respectively, cause the tumor syndrome tuberous sclerosis with similar phenotypes. Until
now, over 50 proteins have been demonstrated to interact with hamartin and/or tuberin.
Besides tuberin, the proteins DOCK7, ezrin/radixin/moesin, FIP200, IKKβ, Melted, Merlin,
NADE (p75NTR), NF-L, Plk1 and TBC7 have been found to interact with hamartin. Whereas
Plk1 and TBC7 have been demonstrated not to bind to tuberin, for all the other hamartin …