Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice
H Koike, PA Arguello, M Kvajo… - Proceedings of the …, 2006 - National Acad Sciences
H Koike, PA Arguello, M Kvajo, M Karayiorgou, JA Gogos
Proceedings of the National Academy of Sciences, 2006•National Acad SciencesDisrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility
gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that
introduces a termination codon at exon 7, abolishes production of the full-length protein, and
impairs working memory performance when transferred to the C57BL/6J genetic
background. Our findings provide insights into how DISC1 variation contributes to
schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv …
gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that
introduces a termination codon at exon 7, abolishes production of the full-length protein, and
impairs working memory performance when transferred to the C57BL/6J genetic
background. Our findings provide insights into how DISC1 variation contributes to
schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv …
Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.
National Acad Sciences