[HTML][HTML] Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial …
L Zhao, CA Cuff, E Moss, U Wille, T Cyrus… - Journal of Biological …, 2002 - ASBMB
Targeted gene disruption or overexpression of 12/15-lipoxygenase in mice on the genetic
background of apolipoprotein E or low density lipoprotein-receptor (LDL-R) deficiency has
implicated 12/15-lipoxygenase in atherogenesis. The data support indirectly a role for 12/15-
lipoxygenase in the oxidative modification of low density lipoprotein. In this study we set out
to explore other potential mechanisms for 12/15-lipoxygenase in atherosclerosis using
apolipoprotein B mRNA editing catalytic polypeptide-1/LDL-R double-deficient mice, a …
background of apolipoprotein E or low density lipoprotein-receptor (LDL-R) deficiency has
implicated 12/15-lipoxygenase in atherogenesis. The data support indirectly a role for 12/15-
lipoxygenase in the oxidative modification of low density lipoprotein. In this study we set out
to explore other potential mechanisms for 12/15-lipoxygenase in atherosclerosis using
apolipoprotein B mRNA editing catalytic polypeptide-1/LDL-R double-deficient mice, a …