[HTML][HTML] Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and …
HXA Yeang, JM Hamdam, LMA Al-Huseini… - Journal of Biological …, 2012 - ASBMB
Dendritic cells (DCs) are critical mediators of immunity and immune tolerance by
orchestrating multiple aspects of T cell activation and function. Immature DCs (iDCs)
expressing low levels of co-stimulatory receptors are highly efficient at antigen capture but
are poor activators of T cells. Maturation of DCs is associated with increased expression of
co-stimulatory molecules. Co-stimulatory receptor gene expression is regulated by
intracellular redox, NF-κB, and MAPK pathways and by histone deacetylase (HDAC) activity …
orchestrating multiple aspects of T cell activation and function. Immature DCs (iDCs)
expressing low levels of co-stimulatory receptors are highly efficient at antigen capture but
are poor activators of T cells. Maturation of DCs is associated with increased expression of
co-stimulatory molecules. Co-stimulatory receptor gene expression is regulated by
intracellular redox, NF-κB, and MAPK pathways and by histone deacetylase (HDAC) activity …