There is growing evidence for the accumulation of phospholipid oxidation products (some of
which can also be formed enzymatically) in several chronic disease processes including
atherosclerosis. There also is considerable evidence that enzymes involved in hydrolysis of
these phospholipids (present in both lipoproteins and cells) may be important in regulation
of atherogenesis. In vitro studies suggest that these lipids can activate vascular wall cells to
states that contribute to the atherosclerotic process. This review focuses on two types of …