[HTML][HTML] Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis
P Pakneshan, M Szyf, R Farias-Eisner… - Journal of Biological …, 2004 - ASBMB
Metastasis is a leading cause of mortality and morbidity in cancer. Urokinase (uPA), only
expressed by the highly invasive cancer cells, has been implicated in invasion, metastases,
and angiogenesis of several malignancies including breast cancer. Because uPA
expression is strongly correlated with its hypomethylated state, we utilized the uPA gene in
the highly invasive MDA-231 human breast cancer cells as a model system to test the
hypothesis that pharmacological reversal of the uPA promoter hypomethylation would result …
expressed by the highly invasive cancer cells, has been implicated in invasion, metastases,
and angiogenesis of several malignancies including breast cancer. Because uPA
expression is strongly correlated with its hypomethylated state, we utilized the uPA gene in
the highly invasive MDA-231 human breast cancer cells as a model system to test the
hypothesis that pharmacological reversal of the uPA promoter hypomethylation would result …