Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization
S Selvarajah, M Yoshimoto, G Maire, J Paderova… - Cancer genetics and …, 2007 - Elsevier
Osteosarcoma (OS) is an aggressive bone tumor characterized by complex abnormal
karyotypes and a high level of genomic instability. Using high-resolution array comparative
genomic hybridization (aCGH), a novel class of localized copy number variations called
microaberrations has been detected. These genomic anomalies typically involve DNA
imbalances affecting 700 kb to 1 Mb DNA, and are often associated with some type of
genetic syndromes. Because the origin of instability in OS is poorly understood, we used …
karyotypes and a high level of genomic instability. Using high-resolution array comparative
genomic hybridization (aCGH), a novel class of localized copy number variations called
microaberrations has been detected. These genomic anomalies typically involve DNA
imbalances affecting 700 kb to 1 Mb DNA, and are often associated with some type of
genetic syndromes. Because the origin of instability in OS is poorly understood, we used …