Protein kinases—the major drug targets of the twenty-first century?
P Cohen - Nature reviews Drug discovery, 2002 - nature.com
Nature reviews Drug discovery, 2002•nature.com
Protein phosphorylation regulates most aspects of cell life, whereas abnormal
phosphorylation is a cause or consequence of disease. A growing interest in developing
orally active protein-kinase inhibitors has recently culminated in the approval of the first of
these drugs for clinical use. Protein kinases have now become the second most important
group of drug targets, after G-protein-coupled receptors. Here, I give a personal view of
some of the most important advances that have shaped this field.
phosphorylation is a cause or consequence of disease. A growing interest in developing
orally active protein-kinase inhibitors has recently culminated in the approval of the first of
these drugs for clinical use. Protein kinases have now become the second most important
group of drug targets, after G-protein-coupled receptors. Here, I give a personal view of
some of the most important advances that have shaped this field.
Abstract
Protein phosphorylation regulates most aspects of cell life, whereas abnormal phosphorylation is a cause or consequence of disease. A growing interest in developing orally active protein-kinase inhibitors has recently culminated in the approval of the first of these drugs for clinical use. Protein kinases have now become the second most important group of drug targets, after G-protein-coupled receptors. Here, I give a personal view of some of the most important advances that have shaped this field.
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