High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
Nature genetics, 2006•nature.com
Here we show that in substantia nigra neurons from both aged controls and individuals with
Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA)(controls,
43.3%±9.3%; individuals with Parkinson disease, 52.3%±9.3%). These mtDNA mutations
are somatic, with different clonally expanded deletions in individual cells, and high levels of
these mutations are associated with respiratory chain deficiency. Our studies suggest that
somatic mtDNA deletions are important in the selective neuronal loss observed in brain …
Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA)(controls,
43.3%±9.3%; individuals with Parkinson disease, 52.3%±9.3%). These mtDNA mutations
are somatic, with different clonally expanded deletions in individual cells, and high levels of
these mutations are associated with respiratory chain deficiency. Our studies suggest that
somatic mtDNA deletions are important in the selective neuronal loss observed in brain …
Abstract
Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA) (controls, 43.3% ± 9.3%; individuals with Parkinson disease, 52.3% ± 9.3%). These mtDNA mutations are somatic, with different clonally expanded deletions in individual cells, and high levels of these mutations are associated with respiratory chain deficiency. Our studies suggest that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.
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